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L-carnitine activates the AKT/FOXO3a/MaFbx pathway, increases p70S6k protein expression, and promotes p-p70S6k phosphorylation to ameliorate the muscle wasting of cancer cachexia in CT26-bearing mice In our in vivo study, p-Akt and p-FOXO3a were decreased in CT26 tumor-bearing mice, and FOXO3a and MAFbx were increased, which could partly explain the muscle loss in the cachectic mice (Fig

Differential effects of reduced mineralocorticoid receptor activation by unilateral adrenalectomy vs mineralocorticoid antagonist treatment in patients with primary aldosteronism - implications for depression and anxiety

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Beyond Weight: Cardiometabolic and Organ Effects Weight is the headline endpoint, but both programs have explored effects that matter metabolically